Hannibal has been imprisoned for three years at the Baltimore State Hospital when a new villain emerges in one Francis Dolarhyde. Jack reaches out to Will to help him track down the brutal serial killer.
The search for serial killer Francis Dolarhyde heats up as Will delves into dangerous territory. He envisions himself in Dolarhyde's psyche and contacts Hannibal Lecter for help in profiling the killer.
Will hatches a cunning plot to slay Francis Dolarhyde, using Hannibal Lecter in his ploy. Bedelia voices concern about the perilous plan as Will continues his game with Hannibal, though Will may have to face his darkest fears.